Procedure and Current Results.
Using a variety of search engines, including PubMed and Google Scholar, we regularly and continually scan as wide a range of publications in neuroscience and cell biology in selected fields as possible. At present these fields include ‘exosomes’, ‘synchronized gamma oscillations’, ‘homeoproteins and Otx2’, ‘claustrum’, ‘telocytes’, ‘nanotunnels’ and others. Then we try and construct an hypothesis, or a series of alternate testable hypotheses, that explain the data. Following this method we have been able to produce
- a detailed hypothesis of the function of the claustrum (Smythies et al. 2012, 2014). This involves linking the Pearson rule with synchronized gamma oscillations in corticoclaustral circuits.
- the first hypothesis relating to the global function of exosomes in the nervous system as a epigenetic code. (Smythies and Edelstein 2013a, Edelstein and Smythies 2014e). This links the discovery of exosomes in the brain in cell biology with clinical data on reafferentation plasticity in the brain in neurology.
- epigenetic aspects of telocyte function including an hypothesis of their basic mode of operating (Smythies and Edelstein 2013c, Edelstein and Smythies 2014a,b). This asks the question of how telocytes, with their remarkable anatomy, could act as information processors in tissues.
- a new hypothesis explaining how acquired characteristics are inherited—Lamarck resurrected (Smythies et al. 2014b). This develops the role of exosomes in transmission of epigenetic information in fertilization.
- a detailed hypothesis on gut-brain interactions involving exosomes: together with Lesley Smythies (Smythies and Smythies 2104a,b). This is based on an analysis of the role of exosomes in gut-brain integration.
- an hypothesis on the role of iron-catecholamine cycling in hydrogen peroxide synthesis in the brain (Smythies and Edelstein 2014c). This links the O’Brien cycle in organic chemistry with the clinical observation of the desferrioxamine-prochlorperazine coma.
Further developments have been published in our other papers (Smythies and Edelstein 2013b, c; Edelstein and Smythies 2013 a, b; Edelstein et al. 2014b,d).
“When one has eliminated the impossible whatever remains, however improbable, must be the truth.”